Search Clinical Trials
Thank you for your interest in research at UTMB! Taking part in research is one way to be part of tomorrow’s healthcare discoveries. UTMB is always looking for volunteers just like you so that our researchers can better understand how to prevent, diagnose, and treat diseases. Everyone is needed. Both healthy volunteers and people with health conditions can help us answer important questions that impact the health of our communities. Ready to start searching for a study to be involved with? • Enter a health condition or leave it blank if you are looking to join any study as a healthy volunteer • Enter your gender and age • Click “View Results” • Click on the study titles for information • Click on the “Contact/Details” tab to get information for contacting the study team
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A Study to Learn About Variant-Adapted COVID-19 RNA Vaccine Candidate(s) in Healthy Children
BioNTech SE
SARS-CoV-2 Virus
Severe Acute Respiratory Syndrome Coronavirus 2
COVID-19
The purpose of this clinical trial is to learn about the safety, extent of the side
effects, and immune responses of the study vaccine (called variant-adapted BNT162b2
RNA-based vaccine) in healthy children. The trial is divided into 5 individual studies or
substudies based on age group and prior h1 expand
The purpose of this clinical trial is to learn about the safety, extent of the side effects, and immune responses of the study vaccine (called variant-adapted BNT162b2 RNA-based vaccine) in healthy children. The trial is divided into 5 individual studies or substudies based on age group and prior history of COVID-19 vaccinations. All participants in each of the 5 sub-studies will receive study vaccine as a shot depending on what group they are in. - Substudy A design: Phase 1 includes participants 6 months through less than 4 years 3 months of age who have not received a previous coronavirus vaccination (COVID-19 vaccine naïve) and will receive 3 doses of study vaccine as their initial series, followed by a fourth dose of study vaccine. Phase 2/3 includes participants 6 months through less than 5 years of age who have not received a previous coronavirus vaccination (COVID-19 vaccine naive) and will receive 1, 2, or 3 doses of study vaccine, depending on what group they are in. - Substudy B design: includes participants 6 months through less than 5 years of age who have either received 2 or 3 prior doses of BNT162b2 and will receive study vaccine as their third or fourth dose. - Substudy C design: Phase 1 includes participants 6 months through less than 5 years of age who have received 3 prior doses of BNT162b2 and will receive study vaccine as their fourth dose. - Substudy D design: includes participants 5 through less than12 years of age who have received 2 or 3 prior doses of BNT162b2 and will receive study vaccine as their third or fourth dose. - Substudy E design: includes participants 2 through less than 12 years of age who have not received a previous coronavirus vaccination (COVID-19 vaccine naive) and will receive a single dose of study vaccine. Type: Interventional Start Date: Sep 2022 |
Correlates of CRCI and Gut Microbiome Dysbiosis; a Pilot Study
The University of Texas Medical Branch, Galveston
Cancer
The aim of this study is to characterize the microbiome and assess fatigue and cognition
of patients with cancer undergoing standard of care treatment. expand
The aim of this study is to characterize the microbiome and assess fatigue and cognition of patients with cancer undergoing standard of care treatment. Type: Observational Start Date: Mar 2024 |
Effectiveness of Healthy Habits for Hospitalized Older Adults to Optimize Rehabilitation
Baylor College of Medicine
Insomnia
Pain
Osteoarthritis, Knee
Osteoarthritis, Hip
This study aims to evaluate behavioral interventions in conjunction with medical
rehabilitation to promote functional health in patients recovering from orthopedic
surgery. Half of the subjects in this study will be assigned to an intervention that
meets with a study therapist to discuss implementi1 expand
This study aims to evaluate behavioral interventions in conjunction with medical rehabilitation to promote functional health in patients recovering from orthopedic surgery. Half of the subjects in this study will be assigned to an intervention that meets with a study therapist to discuss implementing healthy habits. The other half of subjects will assigned to an intervention group that meets with a study therapists to discuss implementing healthy sleep habits. Both groups will undergo several physical and cognitive assessments. Type: Interventional Start Date: Apr 2021 |
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine The1
NRG Oncology
Breast Cancer
This Phase III Trial will determine whether adjuvant chemotherapy (ACT) added to ovarian
function suppression (OFS) plus endocrine therapy (ET) is superior to OFS plus ET in
improving invasive breast cancer-free survival (IBCFS) among premenopausal, early- stage
breast cancer (EBC) patients with es1 expand
This Phase III Trial will determine whether adjuvant chemotherapy (ACT) added to ovarian function suppression (OFS) plus endocrine therapy (ET) is superior to OFS plus ET in improving invasive breast cancer-free survival (IBCFS) among premenopausal, early- stage breast cancer (EBC) patients with estrogen receptor (ER)-positive, HER2-negative tumors and 21-gene recurrence score (RS) between 16-25 (for pN0 patients) and 0-25 (for pN1 patients). Type: Interventional Start Date: Aug 2023 |
Virtual Reality-Integrated Propulsion Feedback for Stroke Rehab
The University of Texas Medical Branch, Galveston
Stroke
Robot Assisted Gait Training
Virtual Reality
This study evaluates a novel Virtual Reality (VR)-integrated visual feedback system
designed to enhance limb propulsion during robot-assisted gait rehabilitation in
individuals post-stroke. In collaboration with CUREXO, a rehabilitation robotics company,
the system is embedded within the Morning Wa1 expand
This study evaluates a novel Virtual Reality (VR)-integrated visual feedback system designed to enhance limb propulsion during robot-assisted gait rehabilitation in individuals post-stroke. In collaboration with CUREXO, a rehabilitation robotics company, the system is embedded within the Morning Walk® end-effector robot and provides real-time visual feedback to facilitate symmetrical use of the paretic and non-paretic limbs. The goal is to address gait asymmetry commonly observed in hemiparetic stroke survivors by promoting improved paretic leg propulsion, which is a key contributor to forward movement during walking. A total of 30 participants (15 stroke, 15 healthy controls) aged 20 years or older will undergo single-session gait training using the VR-robot system. Participants will be assessed using spatiotemporal gait parameters, muscle activity, foot pressure, and vertical ground reaction forces. Additional safety measures-including a saddle-type weight support and real-time heart rate monitoring via smartwatch-are implemented to ensure a safe and controlled training environment. This study aims to test the feasibility and effectiveness of this VR-based system in improving gait symmetry and functional walking capacity in people recovering from stroke. Type: Interventional Start Date: Jul 2025 |
The Effect of Clinic Visit Audio Recordings for Self-management in Older Adults
Dartmouth-Hitchcock Medical Center
Diabetes
The objective of this study is to conduct a multisite trial evaluating the impact of
adding an audio recording of clinic visits (AUDIO) to usual care in older adults with
multimorbidity, including diabetes, compared to After Visit Summary (AVS) alone (Usual
Care; UC). expand
The objective of this study is to conduct a multisite trial evaluating the impact of adding an audio recording of clinic visits (AUDIO) to usual care in older adults with multimorbidity, including diabetes, compared to After Visit Summary (AVS) alone (Usual Care; UC). Type: Interventional Start Date: Dec 2023 |
The Protrieve PROTECTOR Study
Inari Medical
Venous Thromboembolism
Deep Venous Thrombosis
The Protrieve PROTECTOR Study is a prospective, single-arm, multicenter study of the
Protrieve Sheath. expand
The Protrieve PROTECTOR Study is a prospective, single-arm, multicenter study of the Protrieve Sheath. Type: Interventional Start Date: Mar 2025 |
A Study of mRNA-1647 Cytomegalovirus Vaccine in Healthy Participants 9 to 15 Years of Age and Parti1
ModernaTX, Inc.
Cytomegalovirus
The main purpose of study is to evaluate the safety and immunogenicity of different dose
levels of mRNA-1647 versus control in healthy cytomegalovirus (CMV)-seronegative and
CMV-seropositive female and male participants 9 to 15 years of age. In addition,
mRNA-1647 will be evaluated in female partic1 expand
The main purpose of study is to evaluate the safety and immunogenicity of different dose levels of mRNA-1647 versus control in healthy cytomegalovirus (CMV)-seronegative and CMV-seropositive female and male participants 9 to 15 years of age. In addition, mRNA-1647 will be evaluated in female participants 16 to 25 years as a comparator cohort. Type: Interventional Start Date: Nov 2022 |
Novel Strategies for Reducing Burn Scar Itch
The University of Texas Medical Branch, Galveston
Burn Scar
Itch Scarring
Wound
The purpose of the study is to see whether using diphenhydramine (Benadryl), famotidine
(Pepcid), and cromolyn sodium will decrease burn scar itch. expand
The purpose of the study is to see whether using diphenhydramine (Benadryl), famotidine (Pepcid), and cromolyn sodium will decrease burn scar itch. Type: Interventional Start Date: Mar 2025 |
Respiratory Knowledge Portal Computer and Phone Application to Improve Quality of Mechanical Ventil1
The University of Texas Medical Branch, Galveston
Ventilation
ARDS
Respiratory Failure
Mechanical Ventilation
Ventilator-induced Lung Injury (VILI)
Ventilator associated events (VAE) is a quality metric defined by 48 hours of stability
followed by 48 hours of escalation of ventilator settings within the ICU. VAE have been
associated with poor outcomes and increases the cost of care, yet is not easy to avoid.
Operationalizing all the standards1 expand
Ventilator associated events (VAE) is a quality metric defined by 48 hours of stability followed by 48 hours of escalation of ventilator settings within the ICU. VAE have been associated with poor outcomes and increases the cost of care, yet is not easy to avoid. Operationalizing all the standards of care known to improve outcomes of those requiring mechanical ventilation in the critical care environment requires a comprehensive approach. ICU teams are encouraged to follow best practice protocols to help liberate and prevent VAEs. Yet, compliance with protocols in most ICUs is suboptimal for multiple reasons. With the advent of computerized mechanical ventilators capable of streaming data from breath to breath and biomedical integration systems (BMDI) such as Capsule (UTMB's BMDI system), software systems have been developed to help identify variances in the standard of care. Automation in near real-time ventilator data feedback has been shown to reduce the incidences of VAEs. This quality improvement project will leverage Vyaire's Respiratory Knowledge Portal (RKP) to collect and store meaningful data regarding ventilator-associated events (VAE), alarm policy compliance, ventilator weaning, and lung protective analytics. Goals: 1. To collect quality metrics utilizing RKP from patients requiring mechanical ventilation over a 3-4-month period for a retrospective baseline analysis. 2. Provide the RKP tool to the ICU team to determine if the use of RKP's webportal and Messenger Zebra phone app improves quality of mechanical ventilation and outcomes. 3. To determine a return on investment (ROI) for a software system like RKP. Type: Interventional Start Date: Jun 2024 |
Healthy Communities Through CHW Initiatives
The University of Texas Medical Branch, Galveston
Diabetes Mellitus, Type 2
Diabetes Mellitus Risk
Latino(a)s suffer from poor social determinants of health (SODH) conditions more than
non-minority populations, and being a minority is risk factor alone for diabetes. In the
proposed study, investigators will assist church members in becoming Community Health
Workers (CHWs), train them in diabetes1 expand
Latino(a)s suffer from poor social determinants of health (SODH) conditions more than non-minority populations, and being a minority is risk factor alone for diabetes. In the proposed study, investigators will assist church members in becoming Community Health Workers (CHWs), train them in diabetes, and to track the ability to address healthcare access and quality barriers using an online platform. Type: Interventional Start Date: Aug 2023 |
A Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of VAX-31 in Healthy Infa1
Vaxcyte, Inc.
Pneumococcal Vaccines
The objective of the study is to evaluate the safety, tolerability, and immunogenicity of
4 injections of VAX-31 (at 3 dose levels) compared to PCV20 in infants at 2, 4, 6, and
12-15 months of age, in addition to receiving routine US concomitant vaccines. Stage 1 of
the study will comprise 3 dose a1 expand
The objective of the study is to evaluate the safety, tolerability, and immunogenicity of 4 injections of VAX-31 (at 3 dose levels) compared to PCV20 in infants at 2, 4, 6, and 12-15 months of age, in addition to receiving routine US concomitant vaccines. Stage 1 of the study will comprise 3 dose ascending cohorts. Stage 2 of the study will enroll the remainder of the sample size. Type: Interventional Start Date: Nov 2024 |
Leveraging Video Logs as a Bridge to Pre-exposure Prophylaxis (PrEP) With Tailored Messaging to Bla1
The University of Texas Medical Branch, Galveston
HIV Prevention
The primary objective of this R34 proposal is to increase willingness for PrEP initiation
and PrEP initiation among Cisgender Black Women (CBW) and increase willingness to
prescribe/refer pre-exposure prophylaxis (PrEP) to CBW among healthcare providers (HCPs)
in Houston/Harris County, a high prior1 expand
The primary objective of this R34 proposal is to increase willingness for PrEP initiation and PrEP initiation among Cisgender Black Women (CBW) and increase willingness to prescribe/refer pre-exposure prophylaxis (PrEP) to CBW among healthcare providers (HCPs) in Houston/Harris County, a high priority Ending the HIV Epidemic (EHE) jurisdiction. Type: Interventional Start Date: Jan 2025 |
Longitudinal Study of the Porphyrias
Icahn School of Medicine at Mount Sinai
Acute Porphyrias
Cutaneous Porphyrias
The objective of this protocol is to conduct a longitudinal multidisciplinary
investigation of the human porphyrias including the natural history, morbidity, pregnancy
outcomes, and mortality in people with these disorders. expand
The objective of this protocol is to conduct a longitudinal multidisciplinary investigation of the human porphyrias including the natural history, morbidity, pregnancy outcomes, and mortality in people with these disorders. Type: Observational Start Date: Nov 2010 |
Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants
Duke University
Lactating Women on Select DOI
Breastfed Infants of Mothers on Select DOI
Over half of women in the US who are breastfeeding their infants take prescription drugs.
You are being asked to participate in this study because you are breastfeeding your
infant and are currently taking, as part of your medical care, at least one of the drugs
we are studying. We are interested i1 expand
Over half of women in the US who are breastfeeding their infants take prescription drugs. You are being asked to participate in this study because you are breastfeeding your infant and are currently taking, as part of your medical care, at least one of the drugs we are studying. We are interested in studying drugs commonly prescribed to women who are breastfeeding so we can learn more about the amount of drug that is transferred to breastmilk and estimate how much of drug that is consumed by breastfed infants. Type: Observational Start Date: Oct 2018 |
THRIVE Well Cancer FDTN/Exercise_Creatine Supplementation
The University of Texas Medical Branch, Galveston
Breast Cancer
Breast Cancer Female
Muscle Weakness
The study's purpose is to evaluate whether creatine supplementation can help breast
cancer survivors respond quicker to exercise by improving strength, endurance, and body
composition. We are seeking to compare information collected from healthy woman of the
same age who have never had breast cance1 expand
The study's purpose is to evaluate whether creatine supplementation can help breast cancer survivors respond quicker to exercise by improving strength, endurance, and body composition. We are seeking to compare information collected from healthy woman of the same age who have never had breast cancer to those participants who have had breast cancer and undergone chemotherapy treatment. Type: Interventional Start Date: Oct 2024 |
Optimizing Gait Symmetry After Stroke Using Mechanical Constraints and Sensory Feedback
The University of Texas Medical Branch, Galveston
Stroke
Split-belt Treadmill
Resistance Exercise
Feedback
Gait Training
This single-session study aims to evaluate a novel gait training protocol that integrates
mechanical constraints and sensory feedback to enhance paretic leg propulsion in
individuals post-stroke. The study will include 15 individuals who have experienced a
stroke and 15 healthy adults, each aged 201 expand
This single-session study aims to evaluate a novel gait training protocol that integrates mechanical constraints and sensory feedback to enhance paretic leg propulsion in individuals post-stroke. The study will include 15 individuals who have experienced a stroke and 15 healthy adults, each aged 20 years or older. Participants will walk on both tied-belt and split-belt treadmills under various training conditions, including backward-directed resistance (applied at the pelvis, ankle, or both) and real-time sensory feedback (visual, auditory, or combined). These interventions will be applied individually and in combination to identify the most effective environment for promoting symmetrical gait patterns. Each session will last approximately two hours. The equipment used is non-invasive, and the risk to participants is minimal. Type: Interventional Start Date: Jul 2025 |
A Study of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus and Newborn1
Janssen Research & Development, LLC
Hemolytic Disease of the Fetus and Newborn
The purpose of this study is to assess the effectiveness of nipocalimab when compared to
placebo in decreasing the risk of fetal anemia (a condition in which a baby's red blood
cell volume falls below normal levels while the baby is developing in the womb) with live
neonates in pregnant participant1 expand
The purpose of this study is to assess the effectiveness of nipocalimab when compared to placebo in decreasing the risk of fetal anemia (a condition in which a baby's red blood cell volume falls below normal levels while the baby is developing in the womb) with live neonates in pregnant participants at risk for severe hemolytic disease of the fetus and newborn. Type: Interventional Start Date: Dec 2023 |
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
Stryker Instruments
Lumbar Spinal Stenosis
This prospective longitudinal study will compare incidence rates of Medicare beneficiary
surgical and minimally invasive intervention post index procedure, as well as harms
associated with the MILD procedure, at 24 months post-treatment with MILD, tested against
a control group of similar patients1 expand
This prospective longitudinal study will compare incidence rates of Medicare beneficiary surgical and minimally invasive intervention post index procedure, as well as harms associated with the MILD procedure, at 24 months post-treatment with MILD, tested against a control group of similar patients that have had a comparable procedure. This study will start with patients treated with a study procedure having an index date on or after January 1, 2017, and enrollment will continue until stopped by the sponsor. Type: Observational Start Date: Mar 2017 |
PCORI-CER-1306-03385 Lung Cancer Screening Decision Aid Development and Testing
M.D. Anderson Cancer Center
Health Knowledge, Attitudes, Practice
Objectives:
This protocol addresses the first phase of a larger project funded by the
Patient-Centered Outcomes Research Institute to help heavy smokers make informed
decisions about lung cancer screening with low-dose computed tomography (CT). A separate
IRB protocol will be submitted for the lar1 expand
Objectives: This protocol addresses the first phase of a larger project funded by the Patient-Centered Outcomes Research Institute to help heavy smokers make informed decisions about lung cancer screening with low-dose computed tomography (CT). A separate IRB protocol will be submitted for the larger, comparative study. In this initial development phase, our prototype patient decision aid will be updated to reflect current guidelines about lung cancer screening. The updated aid will then be pilot-tested in a new sample of patients. In addition, several of the study measures will be refined and further developed in preparation for the larger study. The specific aims of the measures and decision aid development phase of this project are as follows: Update the aid to reflect current screening guidelines and refine the aid via cognitive testing with patients/smokers; and pilot test the updated aid for acceptability with patients/smokers. Modify our current measure of lung cancer knowledge, conduct cognitive testing of the new measure with patients/smokers, and evaluate the reliability of the new measure in a sample patients/smokers. Type: Observational Start Date: Jul 2014 |
Study of Mixed Vaccination Schedules With a 21-valent Pneumococcal Conjugate Vaccine and a 20-valen1
Sanofi
Pneumococcal Immunization
This study is a Phase 3, randomized, modified double-blind study which aims to measure
whether the investigational pneumococcal conjugate vaccine PCV21 is safe and can help the
body to develop germ-fighting agents called "antibodies" (immunogenicity) when it is
given after 1 dose, 2 doses, or 3 dos1 expand
This study is a Phase 3, randomized, modified double-blind study which aims to measure whether the investigational pneumococcal conjugate vaccine PCV21 is safe and can help the body to develop germ-fighting agents called "antibodies" (immunogenicity) when it is given after 1 dose, 2 doses, or 3 doses of a licensed 20-valent pneumococcal vaccine compared to when 20-valent pneumococcal vaccine is given as a complete series in infants aged from approximately 2 months (42 to 89 days). The study duration per participant will be up to approximately 19 months. The study vaccines (either PCV21 or 20vPCV) will be administered at approximately 2, 4, 6 and 12 to 15 months of age (MoA). Routine pediatric vaccines will be given as per local recommendations. There will be 6 study visits: Visit (V)01, V02 separated from V01 by 60 days, V03 separated from V02 by 60 days, V04 separated from V03 by 30 days, V05 at 12 months of age until 15 months of age, V06 separated from V05 by 30 days. Type: Interventional Start Date: Feb 2025 |
Non-Invasive Preeclampsia Screening and Biobank
Sequenom, Inc.
Preeclampsia (PE)
Women pregnant between 11-14 weeks gestation will be enrolled with blood samples
collected to evaluate for preeclampsia. expand
Women pregnant between 11-14 weeks gestation will be enrolled with blood samples collected to evaluate for preeclampsia. Type: Observational [Patient Registry] Start Date: Feb 2025 |
JAGUAR Trial: ObJective Analysis to GaUge EVAR Outcomes Through Randomization
Endologix
AAA
AAA - Abdominal Aortic Aneurysm
Prospective, randomized, multi-center study designed to evaluate the outcomes of
commercially available contemporary EVAR in a real-world population. Patients will be
randomized into two device cohorts and compared across the primary endpoints.
Patients will be followed procedurally to discharge,1 expand
Prospective, randomized, multi-center study designed to evaluate the outcomes of commercially available contemporary EVAR in a real-world population. Patients will be randomized into two device cohorts and compared across the primary endpoints. Patients will be followed procedurally to discharge, at 1, 6, 12 months and annually through to 5 years (total follow-up commitment). Type: Interventional Start Date: Sep 2021 |
Cardiogenic Shock Working Group Registry
Tufts Medical Center
Cardiogenic Shock
The Cardiogenic Shock Working Group is a multicenter registry where we collect
de-identified clinical variables from the medical records and follow-up phone calls of
shock patients from multiple institutions and centralize this data to a single registry
for analysis of clinical outcomes. expand
The Cardiogenic Shock Working Group is a multicenter registry where we collect de-identified clinical variables from the medical records and follow-up phone calls of shock patients from multiple institutions and centralize this data to a single registry for analysis of clinical outcomes. Type: Observational [Patient Registry] Start Date: Dec 2017 |
Sildenafil to Prevent and Reduce Cancer Related Cognitive Impairment
The University of Texas Medical Branch, Galveston
Cancer
This study is examining the effects of standard of care cancer treatment as well as a
medication called Sildenafil, on the cancer associated fatigue, cognition and the gut
microbiome. expand
This study is examining the effects of standard of care cancer treatment as well as a medication called Sildenafil, on the cancer associated fatigue, cognition and the gut microbiome. Type: Interventional Start Date: Jun 2025 |