Search Clinical Trials
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Sponsor Condition of Interest |
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Centralized Lung Cancer EARly Detection Among Smokers (CLEAR Study)
M.D. Anderson Cancer Center
Smoking
Lung Cancer
This trial studies how well a centralized care strategy works in improving the quality of
smoking cessation and shared decision making among patients who smoke and are considering
lung cancer screening. The centralized care strategy is a model where smokers eligible
for lung cancer screening are re1 expand
This trial studies how well a centralized care strategy works in improving the quality of smoking cessation and shared decision making among patients who smoke and are considering lung cancer screening. The centralized care strategy is a model where smokers eligible for lung cancer screening are referred to a dedicated tobacco treatment program where they receive both the shared decision-making and initiate smoking cessation counseling prior to their visit with a primary care provider. Utilizing the centralized care model may work better in helping people quit smoking and make informed decisions about lung cancer screening compared to usual care. Type: Interventional Start Date: Jul 2020 |
Low Frequency Ultrasound for Osteoarthritis Healing and Rehabilitation
The University of Texas Medical Branch, Galveston
Osteo Arthritis Knee
Age Related Osteoporosis
Pain
Knee Joint Contracture
The purpose of this study is to determine the safety and effectiveness (how well it
works) of a new experimental ultrasound bath device that uses low frequency ultrasound
(LFU) that may or may not help healing. expand
The purpose of this study is to determine the safety and effectiveness (how well it works) of a new experimental ultrasound bath device that uses low frequency ultrasound (LFU) that may or may not help healing. Type: Interventional Start Date: Jul 2024 |
T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-1
Alliance for Clinical Trials in Oncology
Anatomic Stage IA Breast Cancer AJCC v8
Anatomic Stage II Breast Cancer AJCC v8
Anatomic Stage IIA Breast Cancer AJCC v8
Anatomic Stage IIB Breast Cancer AJCC v8
Anatomic Stage III Breast Cancer AJCC v8
This phase III trial studies how well trastuzumab emtansine (T-DM1) and tucatinib work in
preventing breast cancer from coming back (relapsing) in patients with high risk, HER2
positive breast cancer. T-DM1 is a monoclonal antibody, called trastuzumab, linked to a
chemotherapy drug, called DM1. Tra1 expand
This phase III trial studies how well trastuzumab emtansine (T-DM1) and tucatinib work in preventing breast cancer from coming back (relapsing) in patients with high risk, HER2 positive breast cancer. T-DM1 is a monoclonal antibody, called trastuzumab, linked to a chemotherapy drug, called DM1. Trastuzumab is a form of targeted therapy because it attaches to specific molecules (receptors) on the surface of cancer cells, known as HER2 receptors, and delivers DM1 to kill them. Tucatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving T-DM1 and tucatinib may work better in preventing breast cancer from relapsing in patients with HER2 positive breast cancer compared to T-DM1 alone. Type: Interventional Start Date: Jan 2021 |
Nodify XL2 Classifier Clinical Utility Study in Low to Moderate Risk Lung Nodules
Biodesix, Inc.
Nodule Solitary Pulmonary
Non-small Cell Carcinoma
This study evaluates the how addition of the Nodify XL2 test result impacts the clinical
management of newly identified solid lung nodules assessed as low to moderate risk of
cancer. expand
This study evaluates the how addition of the Nodify XL2 test result impacts the clinical management of newly identified solid lung nodules assessed as low to moderate risk of cancer. Type: Observational Start Date: Dec 2020 |
Testing Olaparib in Patients With Advanced or Metastatic (Cancer That Has Spread) Bladder Cancer an1
National Cancer Institute (NCI)
Advanced Bladder Carcinoma
Advanced Genitourinary System Carcinoma
Metastatic Bladder Carcinoma
Metastatic Genitourinary System Carcinoma
Stage III Bladder Cancer AJCC v8
This phase II trial studies how well olaparib works in treating patients with bladder
cancer and other genitourinary tumors with deoxyribonucleic acid (DNA)-repair defects
that has spread to other places in the body (advanced or metastatic) and usually cannot
be cured or controlled with treatment.1 expand
This phase II trial studies how well olaparib works in treating patients with bladder cancer and other genitourinary tumors with deoxyribonucleic acid (DNA)-repair defects that has spread to other places in the body (advanced or metastatic) and usually cannot be cured or controlled with treatment. PARPs are proteins that help repair DNA mutations. PARP inhibitors, such as olaparib, can keep PARP from working, so tumor cells can't repair themselves, and they may stop growing. Type: Interventional Start Date: Nov 2020 |
PCORI-CER-1306-03385 Lung Cancer Screening Decision Aid Development and Testing
M.D. Anderson Cancer Center
Health Knowledge, Attitudes, Practice
Objectives:
This protocol addresses the first phase of a larger project funded by the
Patient-Centered Outcomes Research Institute to help heavy smokers make informed
decisions about lung cancer screening with low-dose computed tomography (CT). A separate
IRB protocol will be submitted for the lar1 expand
Objectives: This protocol addresses the first phase of a larger project funded by the Patient-Centered Outcomes Research Institute to help heavy smokers make informed decisions about lung cancer screening with low-dose computed tomography (CT). A separate IRB protocol will be submitted for the larger, comparative study. In this initial development phase, our prototype patient decision aid will be updated to reflect current guidelines about lung cancer screening. The updated aid will then be pilot-tested in a new sample of patients. In addition, several of the study measures will be refined and further developed in preparation for the larger study. The specific aims of the measures and decision aid development phase of this project are as follows: Update the aid to reflect current screening guidelines and refine the aid via cognitive testing with patients/smokers; and pilot test the updated aid for acceptability with patients/smokers. Modify our current measure of lung cancer knowledge, conduct cognitive testing of the new measure with patients/smokers, and evaluate the reliability of the new measure in a sample patients/smokers. Type: Observational Start Date: Jul 2014 |
Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy
The George Washington University Biostatistics Center
Obstructive Sleep Apnea of Adult
Preeclampsia
Obstetrical Complications
A randomized controlled trial of 1,500 women to assess whether treatment of obstructive
sleep apnea with continuous positive airway pressure (CPAP) in pregnancy will result in a
reduction in the rate of hypertensive disorders of pregnancy. expand
A randomized controlled trial of 1,500 women to assess whether treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP) in pregnancy will result in a reduction in the rate of hypertensive disorders of pregnancy. Type: Interventional Start Date: Aug 2018 |
Point of Care Ultrasound in Obstetric Triage
The University of Texas Medical Branch, Galveston
Ultrasound
Fetal Monitoring
The research will find out if using portable ultrasound devices by nurses can make it
quicker to get babies from 24 to 32 weeks on the doppler monitor. expand
The research will find out if using portable ultrasound devices by nurses can make it quicker to get babies from 24 to 32 weeks on the doppler monitor. Type: Interventional Start Date: Oct 2023 |
JAGUAR Trial: ObJective Analysis to GaUge EVAR Outcomes Through Randomization
Endologix
AAA
AAA - Abdominal Aortic Aneurysm
Prospective, randomized, multi-center study designed to evaluate the outcomes of
commercially available contemporary EVAR in a real-world population. Patients will be
randomized into two device cohorts and compared across the primary endpoints.
Patients will be followed procedurally to discharge,1 expand
Prospective, randomized, multi-center study designed to evaluate the outcomes of commercially available contemporary EVAR in a real-world population. Patients will be randomized into two device cohorts and compared across the primary endpoints. Patients will be followed procedurally to discharge, at 1, 6, 12 months and annually through to 5 years (total follow-up commitment). Type: Interventional Start Date: Sep 2021 |
Gait Training in Post-Stroke Hemiparesis Hemiparesis
Ko, Mansoo
Stroke
The focus of this study is to optimize the delivery of a combined strength and aerobic
training regimen to individuals with post stroke hemiparesis and reduce overuse and
inefficiencies associated with the nonparetic leg during walking. This study proposes to
use 1) split-belt treadmill and 2) sing1 expand
The focus of this study is to optimize the delivery of a combined strength and aerobic training regimen to individuals with post stroke hemiparesis and reduce overuse and inefficiencies associated with the nonparetic leg during walking. This study proposes to use 1) split-belt treadmill and 2) single belt treadmill walking using split belt simulation software for enhancing symmetrical walking patterns for people with stroke. Type: Interventional Start Date: Jul 2021 |
Sildenafil for Treatment of Urinary Incontinence in Patients With Spinal Cord Injuries
The University of Texas Medical Branch, Galveston
Spinal Cord Injuries
Urinary Incontinence
The goal of this study is to determine whether administration of sildenafil will decrease
urine leakage in patients with spinal cord injuries. expand
The goal of this study is to determine whether administration of sildenafil will decrease urine leakage in patients with spinal cord injuries. Type: Interventional Start Date: Jul 2021 |
Impact of a Telerehabilitation Program With Technology Enhancement on Post-burn Recovery
The University of Texas Medical Branch, Galveston
Burns
The purpose of this study is to examine the effect of participating in a
tele-rehabilitation program after a burn. expand
The purpose of this study is to examine the effect of participating in a tele-rehabilitation program after a burn. Type: Interventional Start Date: Apr 2024 |
Cardiogenic Shock Working Group Registry
Tufts Medical Center
Cardiogenic Shock
The Cardiogenic Shock Working Group is a multicenter registry where we collect
de-identified clinical variables from the medical records and follow-up phone calls of
shock patients from multiple institutions and centralize this data to a single registry
for analysis of clinical outcomes. expand
The Cardiogenic Shock Working Group is a multicenter registry where we collect de-identified clinical variables from the medical records and follow-up phone calls of shock patients from multiple institutions and centralize this data to a single registry for analysis of clinical outcomes. Type: Observational [Patient Registry] Start Date: Dec 2017 |
Intravitreal Injection Site and Perceived Pain
The University of Texas Medical Branch, Galveston
Pain
The objective of this study is to explore the perception of pain during intravitreal
injection related to the distance of the entry site from the limbus. expand
The objective of this study is to explore the perception of pain during intravitreal injection related to the distance of the entry site from the limbus. Type: Observational Start Date: Nov 2022 |
Intravesical BCG vs GEMDOCE in NMIBC
ECOG-ACRIN Cancer Research Group
Non-muscle-invasive Bladder Cancer
The study hypothesis is that BCG naïve non-muscle invasive bladder cancer (NMIBC)
patients treated with intravesical Gemcitabine + Docetaxel (GEMDOCE) will result in a
non-inferior event-free survival (EFS) compared to standard treatment with intravesical
BCG. The purpose of this study is to test w1 expand
The study hypothesis is that BCG naïve non-muscle invasive bladder cancer (NMIBC) patients treated with intravesical Gemcitabine + Docetaxel (GEMDOCE) will result in a non-inferior event-free survival (EFS) compared to standard treatment with intravesical BCG. The purpose of this study is to test whether Gemcitabine + Docetaxel is a better or worse treatment than the usual BCG therapy approach. The primary objective of this study is to determine the event free survival (EFS) of BCG-naïve high grade non-muscle invasive bladder cancer patients treated with intravesical BCG vs Gemcitabine + Docetaxel. Secondary objectives are as follows: to compare changes in cancer-specific and bladder cancer-specific QOL from baseline to treatment between BCG-naïve high grade NMIBC patients receiving BCG and GEMDOCE, to determine the cystectomy free survival (CFS) of BCG-naïve high grade NMIBC patients treated with intravesical BCG vs GEMDOCE, to determine the progression free survival (PFS) of BCG-naïve high grade NMIBC patients treated with intravesical BCG vs GEMDOCE, and to determine the safety and toxicity of BCG-naïve high grade NMIBC patients treated with intravesical BCG vs GEMDOCE. Type: Interventional Start Date: Feb 2023 |
Comparative Effectiveness of Initial OAB Treatment Options Among Older Women at High Risk of Falls
The University of Texas Medical Branch, Galveston
Urinary Bladder, Overactive
Urinary Incontinence
Accidental Falls
The goal of this study is to conduct a randomized pilot multi-arm clinical trial
comparing a standard course of physical therapist provided pelvic floor muscle training
(PFMT) to pharmacologic therapy for the treatment of urgency urinary incontinence (UUI)
or Overactive Bladder (OAB) in older women1 expand
The goal of this study is to conduct a randomized pilot multi-arm clinical trial comparing a standard course of physical therapist provided pelvic floor muscle training (PFMT) to pharmacologic therapy for the treatment of urgency urinary incontinence (UUI) or Overactive Bladder (OAB) in older women at high risk of falling. The central hypotheses for this project are i) a randomized pilot multi-arm clinical trial comparing PFMT to drug treatment for UUI or OAB in older women at high risk of falling is feasible; and ii) treatment approach can influence both UI and fall related outcomes in this patient population. The main questions it aims to answer are: 1) Is a multi-arm clinical trial comparing PFMT to drug treatment for UUI or OAB in older women at high risk of falling feasible? and 2) How does treatment approach influence both OAB and fall related outcomes in this patient population? Women (16 per arm) 60 years and older with UUI or OAB who screen positive for high fall risk will be randomized to one of three standard of care treatment arms and followed for six months. The three treatment arms are i) a 12-week structured behaviorally based pelvic floor muscle training (PFMT) intervention administered by physical therapists in the clinic; ii) a 12-week course of the beta-3 agonist, Mirabegron; and iii) a 12-week course of the antimuscarinic, Trospium Chloride. Researchers will compare study feasibility and OAB symptom related outcomes across the three groups to see if a larger clinical trial is warranted. Type: Interventional Start Date: Sep 2023 |
Stroke Thrombectomy and Aneurysm Registry
Medical University of South Carolina
Stroke
Thromboses, Intracranial
Aneurysm, Brain
This international multi-center registry is used to collect existing information and
outcomes for patients undergoing an operation for treatment of injuries to the brain
including the blockage of blood flow to an area of the brain, an abnormal ballooning of
an artery, abnormal tangling of blood ves1 expand
This international multi-center registry is used to collect existing information and outcomes for patients undergoing an operation for treatment of injuries to the brain including the blockage of blood flow to an area of the brain, an abnormal ballooning of an artery, abnormal tangling of blood vessels, abnormal formation of blood vessels, tearing of vein, and bleeding in the brain. This information is used to help predict outcomes that undergo an operation for treatment of the above-listed brain injuries. Additionally, the information is used to compare techniques and devices' effects on technical and clinical outcomes. Type: Observational [Patient Registry] Start Date: Sep 2019 |
Post-Brain Injury Walking and Balance Recovery Program
The University of Texas Medical Branch, Galveston
Acquired Brain Injury
Stroke
Traumatic Brain Injury
The purpose of this study is to test the efficacy of a walking and balance training
program designed to safely challenge and improve walking performance and balance in
relation to walking speed, strength, endurance, and balance after traumatic brain injury
(TBI).
The aim and primary hypothesis of1 expand
The purpose of this study is to test the efficacy of a walking and balance training program designed to safely challenge and improve walking performance and balance in relation to walking speed, strength, endurance, and balance after traumatic brain injury (TBI). The aim and primary hypothesis of this research project is: Aim) Test and implement a new personalized intervention strategy, in addition to usual and customary care at an inpatient rehabilitation clinic, to improve patient outcomes with secondary conditions associated with impaired balance and walking that typically occur post brain injury. After validation of the locomotor Battery of tests, we will implement a personalized training strategy for individuals based on their battery profile. Hypothesis) Individuals training with this individualized protocol will demonstrate improved walking and balance outcomes and those with lesser pre-intervention impairment will improve at a greater rate than those with greater pre-intervention impairment. Type: Interventional Start Date: Aug 2022 |
Geriatric Recovery Using Inpatient and Post-hospitalization Supplementation
The University of Texas Medical Branch, Galveston
Aging
The purpose of the study is to determine the feasibility of nutritional interventions
designed to help older patients maintain physical function after being in the hospital.
We will test the feasibility and effect of nutritional interventions with whey protein,
collagen or placebo on functional rec1 expand
The purpose of the study is to determine the feasibility of nutritional interventions designed to help older patients maintain physical function after being in the hospital. We will test the feasibility and effect of nutritional interventions with whey protein, collagen or placebo on functional recovery from hospitalization in community dwelling older adults. Type: Interventional Start Date: Jun 2019 |
A Social Media Game to Increase Physical Activity Among Older Adult Women
The University of Texas Medical Branch, Galveston
Aging
This study will test the effects of a social media game on the physical activity of older
adult women. The game will consist of playful weekly challenges that require sharing
photographs on a private social media group and also wearing an activity monitor to track
steps. Participants will be random1 expand
This study will test the effects of a social media game on the physical activity of older adult women. The game will consist of playful weekly challenges that require sharing photographs on a private social media group and also wearing an activity monitor to track steps. Participants will be randomized to this game group or to receive the activity monitor only. Type: Interventional Start Date: Dec 2019 |
Effectiveness of Remote Ischemic Preconditioning for Prevention of Contrast Induced Acute Kidney In1
The University of Texas Medical Branch, Galveston
Contrast-induced Acute Kidney Injury (CI-AKI) Following Coronary Angiogram (CI-AKI)
Contrast-induced Nephropathy Following Coronary Angiogram (CIN)
The use of imaging is increasing in clinical practice, either for diagnosis or
intervention. In these imaging processes, contrast medium (CM) is widely used. However,
CM administration can induce contrast-induced nephropathy (CI-AKI). CI-AKI is the third
most common cause of renal insufficiency, an1 expand
The use of imaging is increasing in clinical practice, either for diagnosis or intervention. In these imaging processes, contrast medium (CM) is widely used. However, CM administration can induce contrast-induced nephropathy (CI-AKI). CI-AKI is the third most common cause of renal insufficiency, and its incidence varies from 2% to 50% depending on patient risk factors; in addition, studies have shown that CI-AKI occurs in 2% to 25% of patients undergoing coronary intervention. CI-AKI is associated with significant mortality and morbidity in patients undergoing coronary angiography or other diagnostic contrast studies. We assessed the latest promising evidence on the ability of remote ischemic preconditioning (RIPC) to reduce the incidence of CI-AKI in patients undergoing Coronary Angiogram (CA) or diagnostic contrast studies such as CT angiogram, while at the same time being a non-invasive, low cost, easy, and safe method with absence of adverse effects. However, more randomized controlled trials are needed to confirm these preliminary results. The aim of this study is to minimize the incidence of CI-AKI at the University of Texas Medical Branch (UTMB). If found to be an effective method, RIPC would help minimize the incidence of CI-AKI in all institutions across the globe, who would adopt this intervention. The primary objective: i) reduce the rise in creatinine to < 0.5 mg/dL post-CA in moderate to high risk patients and ii) reduce the incidence of renal replacement therapy post-CA in moderate to high risk patients; iii) we also aim to establish that RIPC is safe and effective. We hypothesize that the use of RIPC, when added to standard medical therapy (pre-and post-CA hydration), will mitigate the effects of contrast on the renal vasculature and lessen the incidence of CI-AKI in moderate to high risk patients at the University of Texas Medical Branch. The use of iodinated contrast to visually enhance target vasculature is a widely used diagnostic technique that is performed daily at UTMB, and around the world, for the diagnosis and management of a variety of conditions. A common complication of this procedure is acute kidney injury (AKI), generally referred to as contrast-induced nephropathy (CI-AKI). This complication can range from an isolated rise in serum creatinine to severe renal dysfunction necessitating renal replacement therapy. The incidence of CI-AKI has been reported as approximately 2-50%, depending upon the definition and sensitivity of assay employed to assess GFR in the hospital setting. In addition, CI-AKI is associated with significant mortality and morbidity. If proven to be beneficial, RIPC will bring about a reduction in incidence of CI-AKI, and thus help to reduce hospitalization and mortality from renal etiology following a given contrast procedure. Type: Interventional Start Date: Nov 2021 |
Co-administration Study of an Investigational Live-Attenuated Respiratory Syncytial Virus Vaccine i1
Sanofi Pasteur, a Sanofi Company
RSV Immunization
This study is a Phase III, randomized, single-blind, placebo-controlled, multi-center
study to be conducted in healthy infants and toddlers which will be enrolled at
approximately 6 months of age (Cohort 1) and approximately 12 months of age (Cohort 2).
The primary objective of the study will be to1 expand
This study is a Phase III, randomized, single-blind, placebo-controlled, multi-center study to be conducted in healthy infants and toddlers which will be enrolled at approximately 6 months of age (Cohort 1) and approximately 12 months of age (Cohort 2). The primary objective of the study will be to assess non-inferiority of the RSV infant and toddler (RSVt) vaccine antibody response when administered concomitantly with routine pediatric vaccines at 6 months of age (Diphtheria and Tetanus Toxoids and Acellular Pertussis, Inactivated Poliovirus, Haemophilus b Conjugate and Hepatitis B Vaccine [Vaxelis® or Pentacel® and Recombivax HB®] Prevnar 20®, and RotaTeq®), and 12 months of age (M-M-R II, VARIVAX, and Prevnar 20 or per local country recommendations) compared to when administered non-concomitantly. Type: Interventional Start Date: May 2024 |
Chronic Subdural Hematoma Treatment With Embolization Versus Surgery Study
The University of Texas Medical Branch, Galveston
Chronic Subdural Hematoma
The goal of this clinical trial is to test in moderately symptomatic chronic subdural
hematoma (CSDH) patients if middle meningeal artery embolization (MMAE) can be used as an
alternative to conventional open surgery. The main questions it aims to answer are:
- Compared to open conventional sur1 expand
The goal of this clinical trial is to test in moderately symptomatic chronic subdural hematoma (CSDH) patients if middle meningeal artery embolization (MMAE) can be used as an alternative to conventional open surgery. The main questions it aims to answer are: - Compared to open conventional surgery, does MMAE reduce the need for rescue surgery or deaths? - What is the safety of MMAE and conventional open surgery in these patients? Participants will be asked to: - Share their medical history and undergo physical examinations - Have blood drawn - Have CT scans of the head - Answer questionnaires - Undergo MMAE or conventional open surgery - Provide information about possible adverse events Researchers will compare participants in the MMAE group with those in the conventional open surgery group to see if there is a reduced need for rescue surgery or deaths and evaluate safety. Type: Interventional Start Date: Nov 2024 |
POLARx Post Approval Study (POLARx PAS)
Boston Scientific Corporation
Paroxysmal Atrial Fibrillation
To collect clinical data on safety, effectiveness and procedural success of Boston
Scientific's Cardiac Cryoablation System (includes all BSC commercially available
POLARx/POLARx Fit catheters) when used to perform pulmonary vein isolation (PVI) in the
ablation treatment of de novo Atrial Fibrillat1 expand
To collect clinical data on safety, effectiveness and procedural success of Boston Scientific's Cardiac Cryoablation System (includes all BSC commercially available POLARx/POLARx Fit catheters) when used to perform pulmonary vein isolation (PVI) in the ablation treatment of de novo Atrial Fibrillation (AF). Type: Interventional Start Date: Jun 2024 |
Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors
NRG Oncology
Breast Cancer
Cognitive Impairments
This Phase III trial will examine the efficacy of computerized cognitive training methods
on perceived cognitive impairment in breast cancer survivors. expand
This Phase III trial will examine the efficacy of computerized cognitive training methods on perceived cognitive impairment in breast cancer survivors. Type: Interventional Start Date: Apr 2024 |
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