Purpose

The purpose of this study is to compare total opioid consumption by subjects in different treatment groups. Another purpose of this study is to assess how well EXPAREL works, collect any safety data and assess your satisfaction using EXPAREL.

Conditions

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
Female
Accepts Healthy Volunteers
No

Inclusion Criteria

  1. Females 18 years of age and older at screening.
  2. Term pregnancies of 37 to 42 weeks gestation, scheduled to undergo elective C-section.
  3. American Society of Anesthesiology (ASA) physical status 1, 2, or 3.
  4. Able to provide informed consent, adhere to the study visit schedule, and complete all study assessments.

Exclusion Criteria

  1. Subjects who, in the opinion of the study site principal investigator, have a high-risk pregnancy.
  2. Subjects with a pregnancy-induced medical condition or complication.
  3. Subjects with 3 or more prior C-sections.
  4. Pre-pregnancy body mass index >50 kg/m2.
  5. Allergy, hypersensitivity, intolerance, or contraindication to any of the study medications.
  6. Planned concurrent surgical procedure with the exception of salpingo-oophorectomy or tubal ligation.
  7. Severely impaired renal or hepatic function.
  8. Subjects at an increased risk for bleeding or a coagulation disorder.
  9. Concurrent painful physical condition that may require analgesic treatment in the postsurgical period for pain that is not strictly related to the surgery.
  10. Clinically significant medical disease in either the mother or baby that, in the opinion of the investigator, would make participation in a clinical study inappropriate.
  11. History of, suspected, or known addiction to or abuse of illicit drug(s), prescription medicine(s), or alcohol within the past 2 years.
  12. Administration of an investigational drug within 30 days or 5 elimination half-lives of such investigational drug.
  13. Previous participation in an EXPAREL study.
  14. Any clinically significant event or condition uncovered during the surgery that might render the subject medically unstable or complicate the subject's postsurgical course.
  15. Receives the epidural component of combined spinal epidural (CSE) anesthesia during the study.

Study Design

Phase
Phase 4
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Active Comparator
Group 1 (Standard of Care Group)
150 mcg Duramorph® + postoperative multi-modal pain regimen. No EXPAREL TAP infiltration
  • Drug: 150 mcg Duramorph + multi-modal pain regimen
    Intrathecal injection of 150 mcg Duramorph + multi-modal pain regimen.
Experimental
Group 2 (Duramorph + EXPAREL TAP)
50 mcg Duramorph + EXPAREL TAP infiltration + postoperative multi-modal pain regimen.
  • Drug: 50 mcg Duramorph+ EXPAREL + multi-modal pain regimen
    Intrathecal injection of 50 mcg Duramorph + EXPAREL administered via TAP infiltration + multi-modal pain regimen.
Experimental
Group 3 (EXPAREL TAP)
EXPAREL TAP infiltration + postoperative multi-modal pain regimen. No Duramorph.
  • Drug: Exparel TAP + multi-modal pain regimen
    EXPAREL administered via TAP infiltration + multi-modal pain regimen.

Recruiting Locations

The University of Texas Medical Branch
Galveston, Texas 77555-0877
Contact:
Rovnat Babazade, MD

More Details

NCT ID
NCT03853694
Status
Recruiting
Sponsor
Pacira Pharmaceuticals, Inc

Study Contact

Jennifer Gordon, BSN, RN
973-451-4055
jennifer.gordon@pacira.com

Detailed Description

This is a Phase-4, multicenter, randomized, active-controlled study in approximately 182 adult women undergoing elective C-section. All subjects will remain in the hospital for up to 72 hours post surgery.

Subjects will be screened within 30 days prior to surgery. During the screening visit, subjects will be assessed for any past or present medical conditions that in the opinion of the investigator would preclude them from study participation.

After the Informed Consent Form (ICF) is signed, a medical history, surgical history, physical examination, 12-lead electrocardiogram (ECG), vital sign measurements, alcohol breath test and urine drug screen, and clinical laboratory tests (hematology and chemistry) will be performed.

On Day 1, prior to the C-section, eligible subjects will be randomized in a 1:1:1 ratio into one of the three treatment groups listed below:

- Group 1: 150 mcg Duramorph® (SOC arm)+ postoperative multi-modal pain regimen as defined in this protocol. No EXPAREL TAP infiltration following skin-incision closure.

- Group 2: 50 mcg Duramorph + EXPAREL TAP infiltration following skin-incision closure + postoperative multi-modal pain regimen as defined in this protocol.

- Group 3: EXPAREL TAP infiltration following skin-incision closure + postoperative multi-modal pain regimen as defined in this protocol. No Duramorph.

Rescue Medication will be provided, as needed, for all subjects.

Subjects will remain in the hospital for up to 72 hours after surgery.

Total opioid burden and Pain intensity scores using a 10 cm Visual Analog Scale (VAS) will be collected.

Daily pain intensity score (VAS) and all pain medications will be collected through Day 14.

A phone call will be made to each subject on Day 14 and Day 30.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.