Purpose

The goal of this study is to learn how safe V118 Formulation C is in Healthy Adults and how well people tolerate it.

Condition

Eligibility

Eligible Ages
Between 18 Years and 49 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

include but are not limited to the following: - Is in good health before randomization

Exclusion Criteria

  • Has a history of invasive pneumococcal disease or known history of other culture-positive pneumococcal disease within 3 years prior to receiving study vaccination. - Has a history of clinically significant endocrine, GI, cardiovascular, hematological, hepatic, immunological, renal, respiratory, genitourinary, or major neurological (including stroke and chronic seizures) abnormalities or diseases.

Study Design

Phase
Phase 1
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Basic Science
Masking
Triple (Participant, Investigator, Outcomes Assessor)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
V118C
Participants receive intramuscular (IM) injection of V118C in a 2-dose regimen administered on Day 1 and Day 29.
  • Biological: V118C
    Intramuscular Administration
Experimental
V118
Participants receive IM injection of V118 in a 2-dose regimen administered on Day 1 and Day 29.
  • Biological: V118C
    Intramuscular Administration
  • Biological: V118
    Intramuscular Administration
  • Biological: Saline
    Intramuscular Administration
Active Comparator
PREVNAR 20™ + Saline
Participants receive one dose of IM injection of PREVNAR 20™ in a 2-dose regimen on Day 1 followed by one dose of saline on Day 29.
  • Biological: PREVNAR 20™
    Intramuscular Administration
  • Biological: Saline
    Intramuscular Administration

Recruiting Locations

University of Texas Medical Branch ( Site 0001)
Galveston, Texas 77555-1115
Contact:
Study Coordinator
409-772-5767

More Details

Status
Recruiting
Sponsor
Merck Sharp & Dohme LLC

Study Contact

Toll Free Number
1-888-577-8839
Trialsites@msd.com

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.